Minimal Scarring after Garafting a Novel Autologous Skin Substitute

April 27, 2018

Dr. V. Moulin and her colleagues published an article in The Journal of Burn Care and Research on  a study they conducted examining an  autologous self-assembly skin substitute (SASS), comprised of fibroblasts secreting an endogenous extracellular matrix, without any exogenous scaffold.

SASS was used as autologous grafts of 14 severely burned patients for deep-partial thickness and full thickness burn wound coverage. They found that SASS promoted a particularly good healing process and ensuing suppleness.  The integrity of the transplanted SASSs persisted over time with no defect in epidermal regeneration and no significant contractures.  After grafting, the SASS has found to be a have good functional characteristics: minimal contraction and hypertrophic scar as well as long-term durability and tissue regeneration.

The full article can be accessed:

V J Moulin, D Larouche, B Nedelec, I Perreault, L Duranceau, P Bortoluzzi, C Beaudoin Cloutier, H Genest, L Caouette Laberge, A Dumas, A Bussieres, E Boghossian, J Kanevsky, Y Leclerc, J Lee, F A Auger, L Germain; 117 Minimal Scarring after Grafting a Novel Autologous Self-assembly Skin Substitute on Burn Patients, Journal of Burn Care & Research, Volume 39, Issue suppl_1, 9 April 2018, Pages S64, https://doi.org/10.1093/jbcr/iry006.120

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